Despite leading to different joining efficiencies, it has been demonstrated that any defect in DNA-PKcs, XRCC4 or Lig4 C-NHEJ factors promoted a strong trend toward microhomology-mediated repair at DSBs detected in plasmid-rejoining assays ( 18 , 21 ).
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Single-stranded DNA oligomers stimulate error-prone alternative repair of DNA double-strand breaks through hijacking Ku protein.
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