Aberrantly expressed miR-582-3p maintains lung cancer stem cell-like traits by activating Wnt/β-catenin signalling.

Notably, in the TCGA lung cancer cohort, although the difference in OS for patients in late stages did not reach statistical significance (log-rank test, P =0.12), which may have been confounded by the low incidence of death and the small number of censored cases in these subgroups, patients with tumours exhibiting high and low miR-582 expression had median survival times of 1.65 and 3.46 years, respectively, and the cumulative 5-year survival rates for the high- and low-miR-582 subgroup patients were 14.6% and 32.7%, respectively ( Fig. 1b ).

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