Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium.

For exploratory purposes and future hypothesis generation, we also report on nominally significant findings ( P <0.05; two-tailed, uncorrected).

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48 Our prospective meta-analyses strategy generates highly significant findings and may be particularly useful in areas where study samples are traditionally small or for which no comprehensive regional assessment of brain morphology has been pursued—for example, high-risk, medication-naive first-episode, longitudinal medication studies, and comparisons across diagnostic boundaries.

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