Effect of Cyclooxygenase(COX)-1 and COX-2 inhibition on furosemide-induced renal responses and isoform immunolocalization in the healthy cat kidney.

BMC Vet Res · 2015 · PMC4669647 · PMID 26634699

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GFR was significantly decreased with ketoprofen and approached significance for robenacoxib (both doses); it is therefore possible that the COX-1 dependent RAAS response to volume depletion was blunted with ketoprofen, accounting for the lesser effect of robenacoxib on furosemide-induced PRA increase.

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