hBD3-Tg mice treated with polyI:C showed a trend towards enhanced IL-6 induction and reduced CXCL10 induction compared to controls, however these data did not reach significance (see S2 Fig ).
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Human β-Defensin 3 [corrected] Exacerbates MDA5 but Suppresses TLR3 Responses to the Viral Molecular Pattern Mimic Polyinosinic:Polycytidylic Acid.
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It is thus potentially highly significant that we see strong elevation of IL12-p40 subunit in mice injected with both hBD3 and polyI:C.