Combination genetic signature stratifies lower-grade gliomas better than histological grade.

The genetic signature was significant across 149 astrocytic gliomas ( p < 0.0001) and marginally significant between 43 IDHmut-OT tumors and 17 IDHmut tumors with oligodendroglial or oligoastrocytic histology ( p = 0.045) (Fig. 4f and 4g ).

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In the 142 grade II gliomas, 45 IDHmut-OT tumors showed a trend of better prognosis than 24 IDHwt tumors in Kaplan-Meier's curve ( p = 0.351), which in turn showed a trend of better prognosis than 65 IDHmut tumors ( p = 0.097), followed by 8 IDHwt-ET tumors ( p = 0.0001) (Fig. 4b ).

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