Low Concordance With Guidelines for Treatment of Acute Cystitis in Primary Care.

Open Forum Infect Dis · 2015 · PMC4675917 · PMID 26753168

Europe PMC DOI

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a significant trendno p-value reported

A significant trend occurred toward increasing TMP-SMX and toward decreasing nitrofurantoin use.

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an increasing trendno p-value reported

We found an increasing trend for TMP-SMX, which suggests that high use of quinolones was not in response to rising sulfa resistance.

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a decreasing trendno p-value reported

We were surprised to find a decreasing trend for nitrofurantoin, which is exclusively used for UTI and has preserved in vitro efficacy for Escherichia coli over many years of use [ 4 , 18 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.