Different from the minor-groove O 2 -alkyldT lesions ( 39 ), the bypass efficiencies of the major-groove O 4 -alkyldT do not exhibit a clear trend with the sizes of alkyl groups attached to the O 4 position of thymine, which could be attributed to the lack of perturbation of base pairing between O 4 -alkyldT and dG by the substituent groups on the O 4 of thymine ( 9 , 40 ).
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Cytotoxic and mutagenic properties of O4-alkylthymidine lesions in Escherichia coli cells.
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