nearly significantp -value = 0.0964
A hypergeometric test revealed a statistically significant overlap between estrogen responsive genes and up-regulated alcohol regulated genes ( p -value = 5.4x10 -8 ) and nearly significant overlap between down-regulated alcohol responsive genes and estrogen responsive genes ( p -value = 0.0964), suggesting that alcohol does not generally affect ER target genes but rather a specific subset in an apparently non-random manner.