Expression of PAM50 Genes in Lung Cancer: Evidence that Interactions between Hormone Receptors and HER2/HER3 Contribute to Poor Outcome.

In lung adenocarcinoma, many genes such as MKI67 , ANLN, NDC80 , and EXO1 showed highly significant correlations ( P < .0001 or better) with up to 15 other PAM50 genes, suggesting that these genes are concordantly expressed (data not shown).

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The PAM50 panel was prognostic in the ERβ-positive subset with marginal significance (HR 2.47 [95% CI: 0.89-6.89], P = .080, Table 2 ), whereas the seven-gene panel significantly associated with DFS in ERβ-positive stage I cases (HR 2.44 [95% CI: 0.99-5.99], P = .050, Table 2 ).

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For HER2, the mRNA expression level was often very low, and there was a higher mRNA level with IHC scores of 2 (the threshold for an HER2-positive assessment in breast cancer) compared with < 2, but it did not reach statistical significance ( Supplemental Figure 2 ).

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