Studies in the mouse model identify strain variability as a major determinant of disease outcome in Leishmania infantum infection.

In the spleen, while there was a general tendency for the increase in parasite burden between day 15 and day 60, in the case of IMT-151 this increase (0.3 log on average) did not reach statistical significance, while ITMAP-263 and IMT-202 exhibited a 0.7 log increase in spleen parasite burden in the same time interval ( p = 0.0012 and p = 0.0008 between day 15 and day 60, respectively for each parasite strain) (Fig. 3b , d and f ).

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