Controlled Human Malaria Infection (CHMI) differentially affects cell-mediated and antibody responses to CSP and AMA1 induced by adenovirus vaccines with and without DNA-priming.

In contrast to CSP, there was a highly significant negative association between the fold-changes in activities compared to pre-CHMI activities, suggesting that the falls in activities due to CHMI was greatest in 9 subjects with the highest pre-CHMI activities ( Table 1 ; Fig. 5B ).

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There was a weakly significant negative association of fold-change with pre-CHMI activities of the 6 subjects that were positive pre-CHMI or post-CHMI ( Fig. 2A ), but given the small number of positive subjects we include this only for information.

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