Mechanism by Which Caloric Restriction Improves Insulin Sensitivity in Sedentary Obese Adults.

EGP did not change after CR (3 ± 0.3 to 3 ± 0.1 mg ⋅ kgFFM −1 ⋅ min −1 ) and did not change in CON (3 ± 0.8 to 3 ± 0.4 mg ⋅ kgFFM −1 ⋅ min −1 ), whereas the percentage suppression of EGP from fasting to low-dose insulin slightly increased but did not reach statistical significance after CR ( Fig. 2 C and E ).

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