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Patient Safety in Medication Nomenclature: Orthographic and Semantic Properties of International Nonproprietary Names.

PLoS One · 2015 · PMC4689353 · PMID 26701761

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a clear trendno p-value reported
There is a clear trend towards stricter compliance with WHO principles after 1960, as most of the extemely long names (20 characters or more) or those with prohibited (di)graphs were designated in the 1950s.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.