Revealing Different Roles of the mTOR-Targets S6K1 and S6K2 in Breast Cancer by Expression Profiling and Structural Analysis.

PLoS One · 2015 · PMC4689523 · PMID 26698305

Europe PMC DOI

hedged sentences

0.0510

closest p · 1.0× alpha

0.0750

boldest claim

The sentences

reached borderline significancep = 0.051so close (0.05 < p ≤ 0.1)

Genes upregulated with both S6K1 and S6K2 knock-down included the mTORC1 factor Raptor, (which also reached borderline significance for double knock-down, p = 0.051) ( Table 5 ) , as well as the adhesion molecules CDH1, TLN1 (talin1) and CADM4 and the cell cycle associated genes RAD51C and TOP2B.

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borderline significantp = 0.075so close (0.05 < p ≤ 0.1)

The gene BCAS1 was significantly downregulated by both S6K1 and S6K2 siRNA, respectively, and this was also borderline significant with simultaneous S6K1 and S6K2 silencing (p = 0.075).

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