A novel autosomal recessive TERT T1129P mutation in a dyskeratosis congenita family leads to cellular senescence and loss of CD34+ hematopoietic stem cells not reversible by mTOR-inhibition.

Aging (Albany NY) · 2015 · PMC4694062 · PMID 26546739

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a clear trendno p-value reported

Although not statistically significant, there was a clear trend showing that human CD45+ engraftment was impaired in the rapamycin treatment group in all organs analyzed.

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