New findings on primary and acquired resistance to anti-EGFR therapy in metastatic colorectal cancer: do all roads lead to RAS?

Surprisingly, high mRNA levels of HER2 (HR=0.64) and epiregulin (HR=0.89) showed a prognostic association with longer PFS for all patients while a positive trend toward better OS was found for the same genes in the overall population [ 89 , 90 ].

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The results of such analyses have shown a significant benefit associated with the addition of anti-EGFR to chemotherapy in the KRAS/BRAF wild-type population, while the improvements in both PFS and OS among the 70 KRAS wild-type / BRAF mutated patients did not reach statistical significance, likely because of the small size of the B-RAF mutant population included in both the studies.

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