A compendium of DIS3 mutations and associated transcriptional signatures in plasma cell dyscrasias.

[ 13 ] reported that the occurrence of DIS3 mutations in minor subclones was significantly associated with a weaker chemotherapy response as compared to the DIS3 mutations in major subclones, while globally there was only a slight trend towards shorter median overall survival for DIS3 -mutated MM patients as compared to DIS3 wild type ones.

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Interestingly, DIS3 mutation frequency seemed to be slightly higher in extramedullary phases (although this difference did not reach statistical significance, likely due to the relatively small size of pPCL and sPCL series).

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