Prevalence of Metformin Use and the Associated Risk of Metabolic Acidosis in US Diabetic Adults With CKD: A National Cross-Sectional Study.

Medicine (Baltimore) · 2015 · PMC4697969 · PMID 26705203

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only marginally significantno p-value reported

Across CKD stages up to CKD stage 3b, we observed a tendency for significantly lower levels of serum bicarbonate in metformin users with CKD stage 2 and 3a, but only marginally significant lower within CKD stage 3b, as compared to nonmetformin users.

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