Barely Significant
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Unique effects on hepatic function, lipid metabolism, bone and growth endocrine parameters of estetrol in combined oral contraceptives.

Eur J Contracept Reprod Health Care · 2015 · PMC4699469 · PMID 26212489

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When comparing the pooled results of the E 4 /LNG groups with those of the E 4 /DRSP groups, the changes in HDL-cholesterol, total cholesterol and triglycerides were all statistically different, while the changes in LDL-cholesterol did not reach statistical significance.

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