The average frequency of apoptotic cells was 12.7 per HPF in PUMA-deficient tumors and 5.2 in PUMA-positive tumors, but this trend toward more apoptosis in PUMA-deficient tumors did not reach statistical significance ( P > .05).
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Uncoupling of PUMA Expression and Apoptosis Contributes to Functional Heterogeneity in Renal Cell Carcinoma - Prognostic and Translational Implications.
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