Time-Course Analysis of Brain Regional Expression Network Responses to Chronic Intermittent Ethanol and Withdrawal: Implications for Mechanisms Underlying Excessive Ethanol Consumption.

A highly significant number of genes in the green module contained potential base pairing motifs (68% with 8 base motif; 92% with 6 base-pairing match) for mmu-let-7c-1 ( Fig 5a and 5b ).

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In our own analysis of miRNA binding site over-representation among genes of the PFC green module, binding sites for both miR-30a (p = 0.003) and mmu - miR-1a/mmu-miR-206 (p = 0.04) showed nominally significant potential binding motifs among genes in the PFC green module using MiRvestigator Framework ( S15 Table ), suggesting that these miRNA families may be involved in regulation of green module genes beyond Bdnf alone.

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