Barely Significant
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Prophylactic melatonin significantly reduces Alzheimer's neuropathology and associated cognitive deficits independent of antioxidant pathways in AβPP(swe)/PS1 mice.

Mol Neurodegener · 2015 · PMC4702331 · PMID 26159703

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a clear trendno p-value reported
2 , the NonAD and 2xAD mice at 12 and at 15 months of age spent similar amounts of time in the open arms, despite a clear trend to less anxiety (more time spent in the open arms) in the 2xAD/MTNR- mice at 12 months of age.

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