Incretin-like effects of small molecule trace amine-associated receptor 1 agonists.

In isolated human islets, RO5166017 also showed a trend to increasing glucose-dependent insulin secretion, although this effect was not significant ( Figure 1 F). 3.2 TAAR1 agonist improved glucose tolerance During an oral glucose tolerance test (oGTT) in C57BL/6 mice, a single dose of RO5166017 (0.3 mg/kg, p.o.) significantly reduced glucose area under the curve (AUC 0–120 ) by 20% ( Figure 2 A) with no effect on fasting glucose.

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