The transcriptional coregulator PGC-1β controls mitochondrial function and anti-oxidant defence in skeletal muscles.

Moreover, hydrogen peroxide (H 2 O 2 ) levels, quantified using the horseradish peroxidase (HRP; Invitrogen)/Amplex red assay, were slightly increased in gastrocnemius and soleus muscles of mutant mice as compared with control mice, even though it did not reach statistical significance ( Fig. 7b and Supplementary Fig. 6b ).

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