ELF5 isoform expression is tissue-specific and significantly altered in cancer.

In the luminal A, luminal B, and HER2 subtypes, ELF5 was significantly downregulated (fold change 0.02–0.13 compared to normal), while in the basal subtype there was a strong trend for increased ELF5 expression (1.96-fold compared with normal, FDR 0.053 in Limma voom analysis, 1.99-fold compared with normal, FDR 0.0008 in edgeR analysis) (Fig. 4a and Additional file 1 : Figure S4b).

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The luminal A, luminal B, and HER2 groups showed a highly significant decrease in ELF5 level in both the Limma and edgeR analyses.

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