Evidence for genetic regulation of mRNA expression of the dosage-sensitive gene retinoic acid induced-1 (RAI1) in human brain.

Figure 3C shows the statistical analysis of this linear regression, which yielded highly significant P-values for the regression coefficients and overall fit (ANOVA) and an adusted-R 2 (model) of 0.892.

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This analysis revealed a set of common SNPs located within the 5′-upstream region of the gene that showed nominally significant correlations between genotype and RAI1 mRNA expression in both brain regions ( Fig. 1 ).

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