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Low vitamin D and the risk of developing chronic widespread pain: results from the European male ageing study.

BMC Musculoskelet Disord · 2016 · PMC4715359 · PMID 26774507

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We observed a trend towards an increased risk of CWP for those in the lowest quintile of 1,25-(OH) 2 D, though in contrast to our findings with 25-(OH) D, even in the unadjusted analysis this did not reach statistical significance. 1,25-(OH) 2 D has a short half-life and the serum level is dependent on a range of other factors including serum phosphate, calcium and parathyroid hormone levels.

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