Guidance for the practical management of the direct oral anticoagulants (DOACs) in VTE treatment.

J Thromb Thrombolysis · 2016 · PMC4715848 · PMID 26780747

Europe PMC DOI

hedged sentence

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The sentences

quite significantno p-value reported

Clinicians should carefully weigh risk versus benefit of factor concentrate administration as there is no evidence that these agents improve outcomes and the risk of thrombosis is quite significant [ 86 , 87 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.