Colorectal cancer, comorbidity, and risk of venous thromboembolism: assessment of biological interactions in a Danish nationwide cohort.

For DVT, there was a negative trend in IC across increasing levels of comorbidity, indicating that CRC and comorbidity counteract one another, resulting in fewer cases of DVT than would be expected from the two exposures acting independently.

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For PE, there was a positive trend in the IC across increasing levels of comorbidity, indicating that CRC and comorbidity act synergistically to generate more cases of PE than would be expected from the two exposures acting independently.

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