Although sequence variability was higher at CD8+ than CD4+ targets (mean Shannon entropy score 0.056 vs 0.031), this did not reach statistical significance (p=0.34, see online supplementary figure S4A–H).
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The broad assessment of HCV genotypes 1 and 3 antigenic targets reveals limited cross-reactivity with implications for vaccine design.
1
0.3400
0.3400