Glucose Alters Per2 Rhythmicity Independent of AMPK, Whereas AMPK Inhibitor Compound C Causes Profound Repression of Clock Genes and AgRP in mHypoE-37 Hypothalamic Neurons.

AMPK phosphorylation was at least 50% repressed during the 12 h incubation with 5.5 mM glucose, whereas there was a trend that the phosphorylation levels of AMPK were reduced to a lesser extent in the 0.5 mM glucose group ( Fig 2A ), but this did not reach statistical significance.

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