An 8-Month Systems Toxicology Inhalation/Cessation Study in Apoe-/- Mice to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk Tobacco Product, THS 2.2, Compared With Conventional Cigarettes.

Even if there were a few apparently time-related trends (eg, triglycerides in the THS2.2 group in Supplementary Figure 8D ), they were inconsistent (here: compared with the switch group that received the same THS2.2 exposure at months 3–8, and with the decreasing trend in the autoanalyzer results, Figure 2 E) and did not reach statistical significance, given the high variability (for both methods) in all groups including the sham.

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The RBIF for 3R4F CS exposure showed an increasing trend with exposure duration (from 60% at the early time-points to approximately 75% at 8 months).

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