Meta-analysis of lipid-traits in Hispanics identifies novel loci, population-specific effects, and tissue-specific enrichment of eQTLs.

When we restrict the comparisons to the European lead SNPs that are also nominally significant in the Hispanic sample (p < 0.05), the concordance is almost perfect: 100% for total cholesterol (19/19, p-value = 2 × 10 −6 ), 94.4% for HDL cholesterol (17/18, p-value = 7 × 10 −5 ), 100% for LDL cholesterol (15/15, p-value = 3 × 10 −5 ), and 100% for triglycerides (11/11, p-value = 5 × 10 −4 ) ( Supplemental File 4 ).

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For example, eQTLs identified in adipose, muscle and liver showed consistent departure from the null for LDL cholesterol and total cholesterol; in contrast, those mapped in LCLs did not reach significance for these traits (although they were highly significant for the remaining lipids phenotypes) ( Figure S8 ).

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