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Chaperonin GroEL/GroES Over-Expression Promotes Aminoglycoside Resistance and Reduces Drug Susceptibilities in Escherichia coli Following Exposure to Sublethal Aminoglycoside Doses.

Front Microbiol · 2015 · PMC4726795 · PMID 26858694

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a clear trendno p-value reported
Nevertheless, we observe a clear trend that isolates over-expressing GroEL/GroES during growth with sub-lethal streptomycin exposure rapidly acquired reduced susceptibility to the selection drug and also to additional drugs.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.