Effects of Prednisolone on Disease Progression in Antiretroviral-Untreated HIV Infection: A 2-Year Randomized, Double-Blind Placebo-Controlled Clinical Trial.

PLoS One · 2016 · PMC4727920 · PMID 26812052

Europe PMC DOI

hedged sentences

0.0575

closest p · 1.1× alpha

0.1938

boldest claim

The sentences

did not quite reach statistical significancep = 0.0575so close (0.05 < p ≤ 0.1)

The majority of study participants who progressed to this combined endpoint met the CD4 criterion (15 versus 17 for prednisolone and placebo, respectively), whereas only a much smaller fraction of study participants reached the clinical endpoint “onset of AIDS-defining condition” (4 versus 11), and differences in this purely clinical endpoint did not quite reach statistical significance (p = 0.0575).

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did not reach statistical significancep = 0.1938not close (p > 0.1)

The difference in absolute CD4 counts between the two treatment arms did not reach statistical significance (p = 0.1938) ( Fig 8A ).

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