Longitudinal effects of menopausal hormone treatments on platelet characteristics and cell-derived microvesicles.

Within the hormone-treated and placebo groups, there were nominally significant increases ( p < 0.05, uncorrected for multiple comparisons) in platelet number and agonist-activated platelet dense-granular ATP secretion over time, while both basal and agonist activated expression of P-selectin and fibrinogen receptors (PAC-1 binding) tended to decrease within groups ( Table III ).

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