The Chronicity of HIV Infection Should Drive the Research Strategy of NeuroHIV Treatment Studies: A Critical Review.

The authors also noted several differences in baseline characteristics between the treatment arms than could have influenced neurocognitive performance (i.e., the high-CPE arm had numerically lower mean CD4, higher rates of hepatitis C co-infection, and showed a trend for poorer plasma virological suppression, potentially due to antiretroviral instability prior to enrolment).

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