Graded Proteasome Dysfunction in Caenorhabditis elegans Activates an Adaptive Response Involving the Conserved SKN-1 and ELT-2 Transcription Factors and the Autophagy-Lysosome Pathway.

PLoS Genet · 2016 · PMC4734690 · PMID 26828939

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failed to reach statistical significanceno p-value reported

Since we found hsf-1 to be up-regulated in the rpn-10 mutant animals, we measured the expression of several heat-shock protein genes controlled by hsf-1 through the use of Nanostring, and we found a trend towards an increase in the expression of these genes in the rpn-10 mutant, but the differences failed to reach statistical significance ( Fig 3D ).

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