Adipocyte-specific blockade of gamma-secretase, but not inhibition of Notch activity, reduces adipose insulin sensitivity.

A-Nicastrin mice were born at Mendelian frequency, without gross developmental phenotype and unchanged body weight and adiposity with chow- ( Supplemental Figure 4 A, B) or HFD-feeding ( Figure 5 D–F), but in contrast to A-Rbpj mice, A-Nicastrin mice showed a trend towards reduced glucose intolerance and insulin sensitivity as compared to Cre- controls ( Supplemental Figure 4 C, G, H).

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