ES-62 protects against collagen-induced arthritis by resetting interleukin-22 toward resolution of inflammation in the joints.

Independent analysis of individual mice showed that, whereas exposure to ES‐62 resulted in significant suppression of the levels of IL‐17– and also IFNγ‐producing cells, the levels of IL‐22–generating cells were maintained and even increased, although this did not reach statistical significance (Figure 2 C).

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