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Fatigue in primary sclerosing cholangitis is associated with sympathetic over-activity and increased cardiac output.

Liver Int · 2015 · PMC4737110 · PMID 25363895

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Fatigue was more severe and more frequently seen in patients with IBD compared with patients without, although these differences did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.