Barely Significant
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Extrinsic factors can mediate resistance to BRAF inhibition in central nervous system melanoma metastases.

Pigment Cell Melanoma Res · 2016 · PMC4737278 · PMID 26414886

2
hedged sentences
0.8620
closest p · 17.2× alpha
0.8620
boldest claim

The sentences

showed a trendP = 0.862not close (p > 0.1)
Patients with progression within the CNS showed a trend to poorer OS compared to those without (median OS 6.0 months (95% CI: 2.1–9.9) versus 9.0 (95% CI: 7.5–10.5), P = 0.862).

also in 53,322 other papers

highly significantno p-value reported
The different responses seen in the bone and CNS were highly significant.

also in 132,142 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.