An unpaired t test found that the fold change in the number of CD11c+ cells following brain irradiation between non-chimera ( M = 17.7, SD = 2.87) and chimera animals ( M = 12.69), t (9) = 1.469, p = 0.1760) did not reach statistical significance, supporting our contention that the irradiation component of chimera induction did not affect the overall cell response to brain irradiation.
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Brain radiation injury leads to a dose- and time-dependent recruitment of peripheral myeloid cells that depends on CCR2 signaling.
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