New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.

The associations with lipid levels seem to be only partially driven by the nearby APOE locus for which previously highly significant associations with LDL-C 37 , CRP 38 (both rs4420638), HDL-C and TG (rs439401; ref. 37 ) levels have been reported ( Supplementary Fig. 7 ).

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The BF% increasing allele of rs6857 near TOMM40 / APOE is significantly associated with increased overall adiposity (BMI), abdominal adiposity (WHR adjBMI ), visceral adipose tissue (VAT) and liver fat storage, which may be mediating the nominally significant association with increased fasting glucose and risk of T2D ( Table 2 and Supplementary Table 13 ).

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