Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum.

16p13.3 has a cis -effect on MLST8 and possibly PGP Our cis -expression QTL study shows that rs30986 has a highly significant positive correlation with the expression levels of MLST8 in at least 9 brain regions (meta-analysis P =6.9 × 10 −18 , Fig. 2b , Supplementary Fig. 7b ) including the cerebellum (meta-analysis P =4.9 × 10 −5 , see Fig. 2b and Supplementary Table 4 ), temporal cortex, hippocampus and substantia nigra.

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While five gene sets (including DNA helicase) were nominally significant (4.8 × 10 −3 ≤ P ≤2.1 × 10 −2 , Supplementary Table 5 ) these gene sets were not significant after multiple comparison correction (false discovery rate >0.10).

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Overall, we only observed a marginally significant overlap between our cerebellar aging gene set and those related to cognitive decline and dementia in the HRS.

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