Serum S-adenosylmethionine, but not methionine, increases in response to overfeeding in humans.

After 28 days of overfeeding, dietary intakes of fat, protein and total energy increased significantly in the total population ( P <0.001 for all, Table 1 ), and tended to be higher in those who gained more weight; however, this did not reach statistical significance ( Table 1 ).

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