Effects of erlotinib therapy on [(11)C]erlotinib uptake in EGFR mutated, advanced NSCLC.

TBF did not change with erlotinib therapy, TBF showed a positive trend towards correlation with [ 11 C]erlotinib K1, but not with V T .

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Tumor rate constant of [ 11 C]erlotinib influx, i.e., K1, showed a trend towards positive correlation with TBF(E−) and TBF(E+); however, this was not statistically significant ( r s = 0.714, P = 0.058 and r s = 0.405, P = 0.327, respectively, see Fig. 3c ) (see Additional file 1 : Table S4 for detailed results).

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