Metabolic/Proteomic Signature Defines Two Glioblastoma Subtypes With Different Clinical Outcome.

Notably, levels of HER3 pY1289 and SRC resulted as significant covariates (HR = 0.25, p = 0.0175 and HR = 0.14, p = 0.0394, respectively; Cox log-rank test), while FAK expression did not reach statistical significance (HR = 1.55, p = 0.0896; Cox log-rank test, Fig. 5B ).

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Comparing genes differentially expressed between the GSf-like and the GSr-like GSC groups with gene sets from the literature, highly significant overlaps were present with two of the Verhaak GBM subtype signatures (mesenchymal and proneural), two stem-cell signatures 23 24 , and a gene set related to oligodendrocyte differentiation 25 .

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