Although SK-216 administration tended to lower type I collagen α1 chain (COL1A1) mRNA levels in lung tissues, the differences between BLM+DW mice and BLM+SK-216 mice did not reach statistical significance ( Fig 8A ).
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Inhibition of Plasminogen Activator Inhibitor-1 Attenuates Transforming Growth Factor-β-Dependent Epithelial Mesenchymal Transition and Differentiation of Fibroblasts to Myofibroblasts.
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